Researchers conducting a controlled trial on various treatments said in a preliminary report released Friday that dexamethasone appeared to help patients recover from severe COVID-19 cases.
“In patients hospitalized with COVID-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support,” the researchers said in the report, which was published in the New England Journal of Medicine.
Two groups were analyzed: 2,104 patients who received the steroid and 4,321 who received standard care.
About 23 percent of the patients in the first group died, versus 25.7 percent of patients in the other group, within 28 days of being randomly assigned to one of the populations.
The incidence of death was 29.3 percent among patients on invasive mechanical ventilation and receiving dexamethasone. Patients getting standard care and on the ventilation experienced a 41.4 percent incidence of death.
Among those receiving oxygen but not invasive ventilation, the group treated with dexamethasone had an incidence of death of 23.3 percent, versus 26.2 percent for the group receiving usual care.
The incidence of death was higher in the dexamethasone group among those receiving no respiratory support.
Dexamethasone is a glucocorticoid, a type of hormone that reduces inflammation and suppresses the immune system.
The research was conducted as part of the RECOVERY trial, a national trial in the United Kingdom aimed at analyzing prospective treatments for COVID-19.Read More – Source